ParkinsonCanadaV1, Main, Exploration, bibRecord, 002B18

MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons

Identifieur interne : 002B18 ( Main/Exploration ); précédent : 002B17; suivant : 002B19

MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons

Auteurs : Wiplove Lamba [Canada] ; Wendy Prichett [Canada] ; David Munoz [Canada] ; David S. Park [Canada] ; John M. Woulfe [Canada]

Source :

Brain research [ 0006-8993 ] ; 2005.

RBID : Pascal:06-0062122

Descripteurs français

Pascal (Inist)
- Neurotoxine, Mésencéphale, Neurone dopaminergique, Tubuline, Parkinson maladie, Souris, Animal, MPTP.

English descriptors

KwdEn :
- Animal, Dopaminergic neuron, Midbrain, Mouse, Neurotoxin, Parkinson disease, Tubulin.

Abstract

Neuronal intranuclear rodlets (INRs; rodlets of Roncoroni) have been known to neuroanatomists since the turn of the century. However, the functional and/or pathological significance of these structures has remained enigmatic. We recently demonstrated that these structures are immunoreactive for class III β tubulin and for glucocorticoid receptor. Moreover, they are markedly reduced in the temporal cortex of patients with Alzheimer's disease relative to age-matched controls and those with dementia with Lewy bodies, thereby implicating these structures in neurodegenerative disease pathogenesis. The present report represents an experimental pilot study to investigate the possible involvement of INRs in Parkinson's disease (PD). Specifically, we demonstrate significantly increased INRs in dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area in mice treated with the selective catecholaminergic neurotoxin MPTP, relative to saline-treated controls. We have hypothesized that INRs represent an intranuclear sequestrum of monomeric β-tubulin and that their alteration in neurodegeneration may reflect disrupted or abnormal microtubule dynamics. We propose that the increased formation of INRs is related to the demonstrated ability of MPTP to cause microtubule disruption. Because tubulin has also been implicated in the pathogenesis of human PD, it is possible that the results of this study will have important implications for this most common neurodegenerative movement disorder.

Affiliations:

Canada

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to stream PascalFrancis, to step Corpus: 000870
to stream PascalFrancis, to step Curation: 000453
to stream PascalFrancis, to step Checkpoint: 000786
to stream Main, to step Merge: 002E54
to stream Main, to step Curation: 002B18

Le document en format XML

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<front><div type="abstract" xml:lang="en">Neuronal intranuclear rodlets (INRs; rodlets of Roncoroni) have been known to neuroanatomists since the turn of the century. However, the functional and/or pathological significance of these structures has remained enigmatic. We recently demonstrated that these structures are immunoreactive for class III β tubulin and for glucocorticoid receptor. Moreover, they are markedly reduced in the temporal cortex of patients with Alzheimer's disease relative to age-matched controls and those with dementia with Lewy bodies, thereby implicating these structures in neurodegenerative disease pathogenesis. The present report represents an experimental pilot study to investigate the possible involvement of INRs in Parkinson's disease (PD). Specifically, we demonstrate significantly increased INRs in dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area in mice treated with the selective catecholaminergic neurotoxin MPTP, relative to saline-treated controls. We have hypothesized that INRs represent an intranuclear sequestrum of monomeric β-tubulin and that their alteration in neurodegeneration may reflect disrupted or abnormal microtubule dynamics. We propose that the increased formation of INRs is related to the demonstrated ability of MPTP to cause microtubule disruption. Because tubulin has also been implicated in the pathogenesis of human PD, it is possible that the results of this study will have important implications for this most common neurodegenerative movement disorder.</div>
</front>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons

MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri